In a week with plenty of unappealing games, here's my picks:

Colts........Luck vs Fitzpatrick...easy one here
Cleveland......why not, they both suck
Buffalo.......the Pats are a mess, and Kyle Orton is the savior buffalo needed 
Cinncinatti........both teams are schizophrenic, so going with home team here
Jax.........the Bortles regime is here!!! 
GB.......the pack ain't the raiders, and miami is not really good
Minnesota........Megatron hurt....no chance for the lions
Denver.........any reason needed?
Baltimore.........Glennon isn't the answer, and they deserve nothing with those uniforms
SD.....their fans can beat the raiders
Atlanta.......home team again
Seattle......romo throws 6 int's but still says he's the best qb ever
Arizona......ssssssnnnnnooooorrrrre
Philly........should be a fun game
StL........they need one

And my BOLD PICK-------somehow the Raiders lose 2 games this week