I pick old St. Louis tomorrow.  It will be close though.  The other ex-Niner QB in Missouri will make it interesting.

Looks like a fairly decent set of games this weekend.  Better to spend the time in front of the TV instead of dealing with holiday shopping.  Here are my picks:

Steelers should win if nice Big Ben shows up.  Then again the last time he was in Georgia, he was in a bar with coeds and well...
Elis.  I mean when you have to start Colt McCoy, the apocalypse is on hand.
New England.  Get the snowplow driver ready.
KC, although I think Oakland makes this very close.
Indy
Cincy.  Johnny Sleazeball is too much of a distraction.
Baltimore
Best team in the NFC
Carolina, even with out Cam should pull this one out.
Former Houston now of Nashville.  Jets are looking forward to the Marcus Mariotta sweepstakes.
Denver even though it's a road game. Peyton can't suck 3 weeks in a row.
Detroit
Seahawks end the Niners' misery season.
In the best game of the weekend, I call 'America's Team' on this one. 
Monday night is the proverbial coal in the Christmas stocking.  A team that sucks on the road against a team that sucks at home.  Can we call it a tie?  If not I go for Nawlins.